中国循证医学杂志

中国循证医学杂志

SIX6 基因 rs10483727 多态性与原发性开角型青光眼发病关联性的 Meta 分析和试验序贯分析

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目的系统评价 SIX6 基因 rs10483727 多态性与原发性开角型青光眼(POAG)的相关性。方法计算机检索 PubMed、Web of Science、The Cochrane Library、CNKI、WanFang Data 和 VIP 数据库,搜集 SIX6 基因 rs10483727 多态性与 POAG 的病例-对照研究,检索时限均为建库至 2018 年 12 月 28 日。由 2 位评价员独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 Stata 12.0 软件进行 Meta 分析。结果纳入 16 篇文献,17 个病例-对照研究,共 9 886 例患者和 19 663 例对照者。Meta 分析结果显示,在亚洲人群中,rs10483727 多态性与 POAG 发病相关(P 均<0.05);在高加索人群中,rs10483727 多态性与 POAG 发病相关(除超显性基因模型);但非洲人群中未曾发现此相关性(P 值均>0.05)。结论当前证据显示亚洲人群和高加索人群中 SIX6 基因的 rs10483727 多态性与 POAG 发病相关。

ObjectivesTo systematically review the association between the SIX6 gene rs10483727 mutation and primary open angle glaucoma (POAG).MethodsPubMed, Web of Science, The Cochrane Library, CNKI, WanFang Data and VIP databases were searched to collect case-control studies on the SIX6 gene rs10483727 polymorphism and primary open angle glaucoma from inception to December 28th, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Meta-analysis was performed by Stata 12.0 software.ResultsSeventeen case-control studies in 16 papers were included, involving 9 886 patients and 19 663 controls. The results of meta-analysis showed that rs10483727 polymorphism in SIX6 gene was associated with the risk of POAG in the Asians and Caucasians. However, no association was found in the Africans.ConclusionsThe current evidence shows that rs10483727 polymorphism in SIX6 gene is associated with the risk of POAG in the Asians and Caucasians.

关键词: SIX6 基因; 原发性开角型青光眼; 病例-对照研究; Meta 分析; 试验序贯分析

Key words: SIX6; Primary open angle glaucoma; Case-control study; Meta-analysis; Trial sequential analysis (TSA)

引用本文: 李瑞, 孙金芳, 余小金, 王莉娜. SIX6 基因 rs10483727 多态性与原发性开角型青光眼发病关联性的 Meta 分析和试验序贯分析. 中国循证医学杂志, 2019, 19(3): 310-317. doi: 10.7507/1672-2531.201810069 复制

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