中国循证医学杂志

中国循证医学杂志

基于试验序贯分析检验 Cochrane 泌尿外科学组 Meta 分析假阴性结果

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目的 采用试验序贯分析(TSA)检验 Cochrane 泌尿外科学组累积 Meta 分析假阴性结果。 方法 计算机检索 The Cochrane Library(2016 年 6 期)泌尿外科学小组的系统评价,查找具有阴性结果的 Meta 分析。由 2 位研究者独立进行文献筛选和资料提取,然后采用 TSA 0.9β 软件进行 TSA。 结果 共纳入 11 篇文献,包括 12 个 Meta 分析。TSA 结果显示,12 个 Meta 分析中,有 4 个(33%)Meta 分析的结论既未穿过 TSA 界值,也未达到期望信息量,为潜在的假阴性结果。 结论 Cochrane 泌尿外科学组 Meta 分析的部分阴性结果为假阴性,TSA 可以辅助判断 Meta 分析的结果是否为假阴性结果。

Objective To detect the false-negative results of cumulative meta-analyses of Cochrane Urology Group with the trial sequential analysis (TSA). Methods The Urology Group of The Cochrane Library (Issue 6, 2016) was searched to collect meta-analyses with negative results. Two researchers independently screened literature and extracted data of included meta-analyses. Then, TSA was performed using TSA software version 0.9 beta. Results A total of 11 papers involving 12 meta-analyses were included. The results of TSA showed that, four (33%) out of 12 meta-analyses were potentially false-negative results for failing to surpass the trial sequential monitoring boundary and to reach the required information size. Conclusion Some of the negative results of systematic reviews from Cochrane Urology Group was false-negative. TSA can help researchers to identify the false-negative results of meta-analyses.

关键词: 试验序贯分析; Meta 分析; 假阴性结果; Cochrane 系统评价

Key words: Trial sequential analysis; Meta-analysis; False-negative result; Cochrane review

引用本文: 翁鸿, 李晓东, 尹晓红, 宁向辉, 赵宇航, 曾宪涛. 基于试验序贯分析检验 Cochrane 泌尿外科学组 Meta 分析假阴性结果. 中国循证医学杂志, 2017, 17(5): 593-597. doi: 10.7507/1672-2531.201608028 复制

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