• 1 核工业416医院核医学科(成都,610051); 2 四川大学华西医院内分泌代谢科;
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【摘要】 目的  评价简化肾脏病膳食改良试验(MDRDa)方程以及国内两个改良MDRD方程(中国方程1、2)预测中国慢性肾脏病患者肾小球滤过率(glomerular filtration rate,GFR)的适用性。 方法  选择2008年1-12月住院慢性肾病患者250例,用99mTc-DTPA肾动态显像法测定GFR(sGFR),同时测定血清肌酐、尿素氮,根据年龄和性别分别用简化MDRD方程、中国方程1和中国方程2预测GFR,即eGFRa (简化MDRD方程)、eGFR1 (中国方程1)和eGFR2(中国方程2),以sGFR为参考值,将估计的eGFRs进行比较。 结果  各方程eGFRs与sGFR之间呈显著相关关系。其中中国方程2的估算eGFR2与sGFR具有良好的一致性,总体偏差最小,准确性最高。 结论  中国方程2优于简化MDRD方程和中国方程1,可用于中国慢性肾病人群eGFR的计算。
【Abstract】 Objective  To evaluate the applicability of three equations for glomerular filtration rate (GFR) in Chinese patients with chronic kidney disease (CKD). Methods  A total of 250 patients with CKD which were diagnosed according to K/DAQI guidelines between January and December 2008 were selected. GFR were estimated with Chinese equation 1 (eGFR1), Chinese equation 2 (eGFR2) and abbreviated MDRD (eGFRa) separately, and the results were compared with that of 99mTc-DTPA(sGFR). Results  The eGFRs of the three equations were correlated significantly with sGFR. Chinese equation 2 seemed to be the best; eGFR2 showed less bias and higher accuracy than other equations. Conclusion  Chinese equation 2 for estimation of GFR may be more accurate in Chinese CKD patients.

引用本文: 史育红,雷远东,何清,李俊凌,黄慧. 三种肾小球滤过率评估方程在中国慢性肾脏病患者的适用性评价. 华西医学, 2011, 26(1): 26-30. doi: 复制