中国循证医学杂志

中国循证医学杂志

药物经济学系统评价的再评价

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目的 对药物经济学研究的系统评价(pharm-SR)进行再评价。 方法 计算机检索 PubMed、EMbase(Ovid)、The Cochrane Library、NHS EED(Ovid)、CENTRAL、Health Technology Assessment(HTA) Database、CNKI、WangFang Data、VIP 和 CBM 数据库,搜集所有 pharm-SR,检索时限均为建库至 2018 年 5 月 6 日。由 2 名研究者独立筛选文献和提取数据后,对发表期刊类型及影响因子、疾病类型、方法学质量评价结果等进行数据统计和频数分析,采用改良后的 AMSTAR 量表对 pharm-SR 的方法学质量进行评分。 结果 最终纳入 143 篇 pharm-SR。自 2000 年以来 pharm-SR 发表数量在逐渐增加。其中,英国发文量较多(39.8%);pharm-SR 主要发表在 Health Technology AssessmentPharmacoeconomics 上;纳入文献中,以肿瘤相关的 pharm-SR 发表的文献数量最多(20.9%);每篇发表文献平均检索 7.42±4.00 个数据库,除检索常用数据库 MEDLINE、EMbase 和 The Cochrane Library 外,专业数据库主要为 NHS EED 和 HTAD;对药物经济学研究的质量评价工具以 BMJ checklist(20.15%)和 the Drummond checklist(19.40%)为主。改良后的 AMSTAR 量表评价结果显示,pharm-SR 的得分范围为 2~10 分,平均分为 6.89±2.28 分,条目的平均符合率为 67.34%,总体方法学质量中等。 结论 pharm-SR 发表数量和期刊在逐年递增,且研究方法逐渐趋于统一和集中,但研究质量仍有待进一步的提高和完善。

Objectives To survey the systematic reviews of pharmacoeconomic evaluations. Methods Databases including The Cochrane Library, PubMed, EMbase (Ovid), NHS EED (Ovid), CENTRAL, Health Technology Assessment (HTA) Database, CNKI, WanFang Data, VIP and CBM were searched from inception to May 2018 to collect systematic reviews of pharmacoeconomic evaluations. Two reviewers independently screened literature and extracted data. Data statistics and frequency analysis were then conducted on the basic characteristics of included literatures, which involves the publication journal type and influencing factors (IF), disease type, quality assessment tool, etc. The amended AMSTAR scale was used to assess the methodological quality of pharm-SR. Results One hundred and forty-three systematic reviews were included in the overview. The UK had a large number of publications (39.8%), which were mostly published in theHealth Technology Assessment and Pharmacoeconomics. Among the included literatures, most were evaluated tumor related pharmacoeconomics systematic reviews (20.8%). They searched on average 7.42±4.00 databases. The British Medical Journal checklist (20.15%) and the Drummond checklist (19.40) were the main tools for quality evaluation. The methodological qualities of these studies were not high. Conclusions The evidence shows that the number of systematic reviews of pharmacoeconomic is increasing and research methodology is gradually unifying. However, the quality is still required to be further improved.

关键词: 药物经济学; 系统评价; 系统评价再评价

Key words: Pharmacoeconomic; Systematic reviews; Overview of systematic reviews

引用本文: 米雪, 李佳莲, 陈敏, 曾力楠, 黄宗瑶, 宋好鑫, 张伶俐. 药物经济学系统评价的再评价. 中国循证医学杂志, 2019, 19(2): 212-217. doi: 10.7507/1672-2531.201808144 复制

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