中国循证医学杂志

中国循证医学杂志

血压变异性在慢性肾病和血液透析患者中的临床价值

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血压变异性(Blood pressure variability,BPV)是一种新兴的血压相关临床指标。由于显著的血流动力学变化,慢性肾病和血液透析患者的 BPV 水平明显高于单纯高血压人群,这提示 BPV 可能对慢性肾病和血液透析患者具有重要临床价值。近年来,基于慢性肾病和血液透析人群的 BPV 研究结果表明 BPV 对慢性肾病和血液透析患者的靶器官损害、心血管疾病风险具有独立预测价值。本文旨在对这些研究进行概述,并对 BPV 在慢性肾病和血液透析患者的临床意义进行展望和预测。

Blood pressure variability (BPV) is a novel predictor related to blood pressure level, and a large number of studies based on the hypertension cohort have shown that BPV is an independent predictor of target organ damages and cardiovascular adverse outcomes. Due to the significant hemodynamic changes, BPV in patients with chronic kidney disease (CKD) and hemodialysis is higher than the simple hypertension cohort, suggesting that BPV may be of great significance to patients with chronic kidney disease and hemodialysis. In recent years, studies based on CKD and hemodialysis cohort have published in succession whose results revealed that BPV of this cohort is of great prognostic significance for predicting target organ damages and cardiovascular disease risks. This article aims to provide an overview on these research, so as to survey and predict the clinical significance of BPV in CKD and hemodialytic patients.

关键词: 血压变异性; 慢性肾病和血液透析; 靶器官损害; 心血管事件; 全因死亡率

Key words: Blood pressure variability; Chronic kidney disease and hemodialysis; Target organ damage; Cardiovascular event; All-cause mortality

引用本文: 唐嘉敏, 于世凯, 张毅, 徐亚伟. 血压变异性在慢性肾病和血液透析患者中的临床价值. 中国循证医学杂志, 2018, 18(10): 1018-1021. doi: 10.7507/1672-2531.201808069 复制

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