中国循证医学杂志

中国循证医学杂志

国内期刊发表的干预类动物实验报告质量的文献计量分析

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目的 基于 ARRIVE 指南对国内已发表的动物实验的报告质量进行回顾分析。 方法 计算机检索 CNKI、WanFang Data、VIP 和 CBM 数据库,检索时间截止 2018 年 7 月。由 4 名研究者独立筛选文献、提取资料,采用 ARRIVE 指南评价纳入动物实验的报告质量,并根据发表时间对指南各个条目的符合率进行对比分析。 结果 最终纳入 4 342 篇动物实验。其中 73.03%(3 171/4 342)的研究的被引次数≤5 次;仅 29.04% 研究(1 261/4 342)发表在 CSCD 收录的期刊。ARRIVE 指南评价结果显示:超过一半的亚条目(51.28%,20/39)在“低风险”的符合率不足 50%,其中 65.00%(13/20)的亚条目在“低风险”的符合率上低于 10%。 结论 国内动物实验报告质量总体中等偏低。随着 2010 年 ARRIVE 指南的发布,国内动物实验报告在 ARRIVE 指南的大部分条目上的符合率虽得到一定程度的提高,但在方法学、结果及讨论部分内容涉及的一些具体条目存在报告不充分、不完整等问题。因此,我们建议有必要普及 ARRIVE 指南,倡导研究者们遵循 ARRIVE 指南并促进其在相关稿约期刊中的引用,以促进动物实验的设计、实施和报告,最终提升其质量。

Objective Using the ARRIVE guidelines (Animal Research Reporting: In Vivo Experiments Guidelines) to carry out a retrospective study of the reporting quality of animal studies published in Chinese journals. Methods We searched databases including CNKI, WanFang Data, VIP and CBM to July, 2018. Four reviewers independently screened literatures and extracted data. The ARRIVE guidelines were used to assess reporting quality and the comparative analysis based on different published time. Results A total of 4 342 studies were included. About the cited frequency, 3.03% studies were ≤5, and only 29.04% studies were published in journals of CSCD. The assessment results showed that the number of reported items with "low risk" in the ARRIVE guidelines, which have 20 items, that means 39 sub items, more than half of sub items (51.28%, 20/39) rated as "low risk" had a compliance rate of less than 50%. And of these, 65.00% (13/20) of sub items had a lower rate of compliance with "low risk" than 10%. Conclusion The reporting quality of domestic animal studies is generally low. The coincidence rate of domestic animal studies has been improved to some extent in most of items after the ARRIVE guidelines published, but some items of methodology, results and conclusions had problems with insufficient reporting. Therefore, we suggest that it is necessary to popularize the ARRIVE guidelines, advocate more researchers following the ARRIVE guidelines and promote endorsement of the ARRIVE Guideline by Chinese Journals to improve the design, implementation and reporting of animal experiments, and ultimately enhance the quality of animal studies.

关键词: 动物实验; ARRIVE; 报告质量

Key words: Animal experiments; ARRIVE; Reporting quality

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