目的了解我国中医领域真实世界研究热点问题和研究者现况。方法计算机检索 CBM、CNKI、WanFang Data、PubMed 和 EMbase 数据库，搜集目前已发表的所有中医领域的真实世界研究文献，检索时限均从建库至 2018 年 4 月 26 日。使用 Excel 表格提取主要信息（研究内容、资料来源、研究方法），采用 BICOMS-2 软件提取纳入研究的基本信息，并使用 NetDraw 2.084 软件生成网络关系图。结果最终纳入中医领域真实世界研究 373 篇，第一篇发表于 2008 年。发文量为前 3 位的作者排名为谢雁鸣、庄严、杨薇，单位排名为中国中医科学院中医临床基础医学研究所、中国人民大学和中国人民解放军海军总医院。北京市发文量占研究总数的 74.26%。关键词网络关系图结果发现研究热点问题为真实世界、医院信息系统、真实世界研究、联合用药、倾向性评分。研究内容主要为真实世界中药用药（前三位为复方苦参注射液、灯盏细辛注射液、疏血通注射液）。关注度最高的疾病依次为消化系统疾病、神经系统疾病、心血管疾病，具体为中风、冠心病、病毒性肝炎和高血压。58.18% 为回顾性研究，49.60% 的资料来源于医院信息系统，56.30% 使用数据挖掘方法进行统计分析。结论中医领域真实世界研究数据来源多基于医院信息系统，多运用数据挖掘方法对中药制剂用药进行研究。研究者对中药的关注热度高于中医诊疗手段，对中药制剂高于传统中药，而对传统中药、药方及传统诊治手段如艾灸、刮痧等的关注有待提高。
ObjectivesTo analyze the active areas of real world studies on traditional Chinese medicine in China.MethodsCBM, CNKI, WanFang Data, PubMed and EMbase databases were electronically searched to collect real world studies on traditional Chinese medicine in China from inception to 26th April, 2018. The main research contents (research direction, data sources, and research methods) by Excel were extracted, together with the primary information by BICOMS-2 software and production of the network figures by NetDraw 2.084 software.ResultsEventually, 373 real world studies in traditional Chinese medicine were included, in which the initial one was punished in 2008. The top three ranking of authors involved in real world studies on traditional Chinese were Xie Yanming, Zhuang Yan, Yang Wei, and the top three ranking of institutions were Institute of Basic Research in Clinical Medicine of China Academy of Chinese Medical Sciences, School of Statistics of Renmin University of China, and the PLA Navy General Hospital. The amount of related studies in Beijing accounted for 74.26%. It was found that the active areas involve real world, hospital information system, real world study, drug combination, and propensity score method. In terms of the main studied contents on the use of traditional Chinese medicine in the real world, in which the top three were Fufang Kushen injection, Dengzhanxixin injection, and Shuxuetong injection. Digestive system disease, nervous system disease and cardiovascular disease received the highest attention rate, specifically stroke, coronary heart disease, virus hepatitis and hypertension. 58.18% studies were retrospective studies, 49.60% of the information were from the hospital information system, and 56.30% studies used data mining to carry out statistical analysis.ConclusionsMost real world studies on traditional Chinese medicine are based on HIS, and use data mining to study Chinese medicine preparations. The research attention on Chinese medicine is higher than that of the method of diagnosis and treatment, similarly the Chinese medicine preparations is higher than traditional Chinese medicine. In future, attention should be paid to traditional Chinese medicine, prescription and traditional methods of diagnosis and treatment, such as moxibustion and scraping.
Traditional Chinese medicine;
Real world study;
Hospital information system
陈吉, 孙月, 布优祥, 田金徽. 中医领域真实世界研究现状分析. 中国循证医学杂志, 2018, 18(11): 1216-1223. doi: 10.7507/1672-2531.201807103