中国循证医学杂志

中国循证医学杂志

PROSPERO 平台诊断性试验系统评价/Meta 分析的基本特征及合作情况分析

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目的 评价 PROSPERO 平台注册诊断性试验系统评价/Meta 分析的基本特征及合作情况,为研究人员注册和开展诊断性试验系统评价/Meta 分析提供借鉴。 方法 计算机检索 PROSPERO 注册平台,搜集注册的诊断性试验系统评价/Meta 分析,检索时限截至 2017 年 11 月 12 日。由 2 名研究员独立筛选文献、提取资料并采用 STATA 13.0 制作森林图,采用 BICOMS(书目信息共现分析系统)分析软件对国家、作者和单位等信息进行抽取并生成共现矩阵。采用 Ucinet 6.0 软件中 NetDraw 绘制国家、作者和作者单位合作社会网络图。 结果 PROSPERO 平台共注册了 240 个诊断性试验系统评价/Meta 分析,其在作者(1 050 个)、机构(360 个)和国家(34 个)分布方面均不平衡。诊断性试验系统评价/Meta 分析涉及 21 个系统疾病,最多的疾病为肿瘤(52 个,22%);组织活检是使用最多的金标准,影像学诊断是使用最多的诊断试验。检索使用频率最高的外文数据库为 PubMed、EMbase、The Cochrane Library,使用频率最高的中文数据库为 CNKI、WanFang Data 和 CBM。105 个诊断性试验系统评价/Meta 分析(43.8%)报道了检索策略,159 个(66.3%)使用 QUADAS-2 评价纳入研究质量,105 个(43.8%)报告了基金资助情况。 结论 PROSPERO 平台注册诊断性试验系统评价/Meta 分析的数量相对较少,作者、机构和国家间存在一定的联系,但对诊断性试验系统评价/Meta 分析的效应指标和统计方法描述不够。

Objective To analyze the cooperation and basic characteristics of systematic reviews/meta-analyses (SRs/MAs) in diagnostic test registered in PROSPERO platform, in order to provide references for registering and preparing the SRs/MAs in diagnostic test. Methods We searched PROSPERO platform from inception to November 12th, 2017, to identify SRs/MAs about diagnostic test. Two reviewers independently screened records and extracted data by inclusion and exclusion criteria. The forest figure was prepared by STATA 13.0 software, the figure of network of authors, organizes and countries were prepared by NetDraw software. Results A total of 240 SRs/MAs in diagnostic test were included, there was a serious imbalance in the number of the distribution of authors (1 050), organizes (360) and countries (34). These SRs/MAs in diagnostic test were related to 21 systematic diseases, and cancer ranked the top one (52, 22%). tissue biopsy was the most used gold standard, imaging diagnosis is the most used diagnostic test. The most commonly retrieved English databases were PubMed, EMbase The Cochrane Library, but Chinese databases were CNKI, WanFang Data and CBM. The search strategy were reported in 105 (43.8%) SRs/MAs in diagnostic test, the QUADAS-2 were used to assess the quality of including studies in 159 (66.3%) SRs/MAs in diagnostic test, 105 (43.8%) SRs/MAs were supported by funding. Conclusion The absolute number of SRs/MAs in diagnostic test is still small, there must be relationships among different authors, organizes and countries, in the future, the researcher should focused on the effective sizes and statistical methods

关键词: PROSPERO; 诊断性试验; 系统评价; Meta 分析; 注册

Key words: PROSPERO; Diagnostic test; Systematic review; Meta-analysis; Register

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