中国循证医学杂志

中国循证医学杂志

清道夫受体 B1 基因(SCARB1)多态性与心血管疾病发病风险相关性的 Meta 分析

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目的 系统评价清道夫受体 B1 基因(SCARB1)变异与心血管疾病(CVD)发病风险的相关性。 方法 计算机检索 PubMed、Web of Science、CNKI、WanFang Data 和 VIP 数据库,检索时限均从建库截至 2017 年 12 月 31 日。由两位研究者独立筛选文献、提取资料和评价纳入研究的偏倚风险后,采用 Stata 12.0 软件进行 Meta 分析。 结果 共纳入 12 个研究,报告了 SCARB1 基因 rs5888 C/T 多态性、rs4238001 G/A 多态性和 rs10846744 G/C 多态性与心血管疾病易感性的相关性。Meta 分析结果显示,rs10846744 G/C 多态性与心血管疾病发病风险相关[G vs. C:OR=1.30,95%CI(1.11,1.52),P=0.001],但 rs5888 C/T 多态性[C vs. T:OR=0.97,95%CI(0.86,1.09),P=0.627]和 rs4238001 G/A 多态性[G vs. A:OR=0.87,95%CI(0.64,1.17),P=0.344]与心血管疾病发病风险不相关。亚组分析结果显示:rs5888 C/T 多态性与非亚洲人群 CVD 的发病风险相关[C vs. T:OR=0.82,95%CI(0.68,0.99),P=0.040]。 结论 SCARB1 rs10846744 G/C 多态性与 CVD 发病风险相关。但受纳入研究的数量和质量的限制,上述结论尚待开展更多高质量研究予以验证。

Objectives To evaluate the relationships between the Scavenger Receptor Class B1 (SCARB1) polymorphisms and susceptibility of cardiovascular diseases (CVDs). Methods Databases including PubMed, Web of Science, CNKI, WanFang Data and VIP were searched from inception to December 31st 2017 to collect case-control studies on relationships between Scavenger Receptor Class B1 (SCARB1) polymorphisms and susceptibility of CVDs. Paper screening, data extraction and assessment of risk of bias were carried out. Meta-analysis was then conducted by Stata 12.0 software. Results In total, 12 studies relevant to SCARB1 rs5888C/T, rs4238001 G/A and rs10846744 G/C polymorphisms were included. Meta-analysis showed that there was no significant association between the rs5888 C/T polymorphism and susceptibility of CVDs (C vs. T: OR=0.97, 95%CI 0.86 to 1.09, P=0.627), neither for the rs4238001 G/A (G vs. A: OR=0.87, 95%CI 0.64 to 1.17, P=0.344). However, the rs10846744 G/C polymorphism was significantly associated with CVDs risk (G vs. C: OR=1.30, 95%CI 1.11 to 1.52, P=0.001). Subgroup analysis showed that, for non-Asian subjects, there was a significant association between the rs5888 C/T polymorphism and susceptibility of CVDs (C vs. T: OR=0.82, 95% CI 0.68 to 0.99, P=0.040). Conclusions SCARB1 rs10864744 G/C polymorphism could be associated with risk of CVDs. Considering the quantity and quality limitation of the included studies, the conclusion has to be verified by more large-scale high quality studies.

关键词: 清道夫受体 B1; SCARB1; 心血管疾病; 基因多态性; Meta 分析

Key words: Scavenger receptor class B1; SCARB1; Cardiovascular disease; Polymorphism; Meta-analysis

引用本文: 何盼, 范思宇, 智宏, 王莉娜. 清道夫受体 B1 基因(SCARB1)多态性与心血管疾病发病风险相关性的 Meta 分析 . 中国循证医学杂志, 2018, 18(10): 1053-1061. doi: 10.7507/1672-2531.201803061 复制

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