中国循证医学杂志

中国循证医学杂志

中国创伤性脊髓损伤流行病学和疾病经济负担的系统评价

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目的系统评价创伤性脊髓损伤(spinal cord injury,SCI)在中国的流行病学特征和疾病经济负担。方法计算机检索 PubMed、EMbase、WanFang Data、VIP 和 CNKI 数据库,搜集有关中国 SCI 流行病学和疾病经济负担的研究,检索时限均从 1978 年 1 月 1 日至 2017 年 8 月 30 日。由 2 名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 Stata 12.0 软件进行合并分析。结果共纳入 32 篇文献。Meta 分析结果显示:我国 SCI 年患病率为 37 人次/100 万[95%CI(21,53)],平均年龄范围 34.7~54.4 岁,男性高于女性。汽车碰撞和高空坠落是 SCI 的主要原因。SCI 严重程度从 A~E 级(ASIA 分级)不等,以 A 级为主,E 级比例最低。结论当前证据显示,我国 SCI 发病率较高,具有较高的社会和医疗负担,SCI 主要由汽车碰撞和高空坠落引起。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。

ObjectiveTo systematically review the epidemiological characteristics and economic burden of traumatic spinal cord injury (SCI) in China.MethodsPubMed, EMbase, WanFang Data, VIP and CNKI databases were electronically searched to collect studies of the epidemiological characteristics and economic burden of SCI in China from January 1st, 1978 to August 30th, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using Stata 12.0 software.ResultsA total of 32 studies were included. The results of meta-analysis showed that: the prevalence of SCI in China was 37 persons per million per year (95%CI 21 to 53), with the average age ranged from 34.7 to 54.4 years. Men had a higher risk of SCI than Women. Motor vehicle collisions (MVCs) and falls were the two main causes of SCI. The neurological injury levels were varied, ASIA grade A was the most common and grade E was the least.ConclusionCurrent evidence shows that there is a high prevalence of SCI in China with heavy social and medical burden. The main reason of SCI is motor vehicle collisions and falls. Due to limited quality and quantity of the included studies, more high-quality studies are needed to verify above conclusion.

关键词: 脊髓损伤; 流行病学; 经济负担; 系统评价

Key words: Spinal cord injury; Epidemiology; Economic burden; Systematic review

引用本文: 陈星月, 陈栋, 陈春慧, 王凯, 唐笠, 李宇哲, 吴爱悯. 中国创伤性脊髓损伤流行病学和疾病经济负担的系统评价. 中国循证医学杂志, 2018, 18(2): 143-150. doi: 10.7507/1672-2531.201712034 复制

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