中国循证医学杂志

中国循证医学杂志

越野行走对心血管疾病预后影响的 meta 分析

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目的系统评价越野行走对心血管疾病预后的影响。 方法计算机检索 PubMed、Web of Science、EMbase、The Cochrane Library、CBM、CNKI 和 VIP 数据库,搜集越野行走对心血管疾病预后影响的干预性研究,检索时限均从建库至 2018 年 6 月。由 2 名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 RevMan 5.3 软件进行 meta 分析。 结果最终纳入 9 个研究,包括 328 例患者。meta 分析结果显示:与对照组相比,越野行走组的低密度脂蛋白(LDL)[MD=–11.38,95%CI(–17.51,–5.25),P=0.000 3]、甘油三酯(TG)[MD=–21.14,95%CI(–32.33,–9.96),P=0.000 2]、收缩压(SBP)[MD=–7.96,95%CI(−11.45,–4.46),P<0.000 01]及血清总胆固醇(TC)、舒张压(DBP)、体重指数(BMI)均有明显好转(P<0.05)。但两组 HDL 的差异无统计学意义。 结论本研究结果显示越野行走可使心血管疾病患者的预后指标有一定改善,但其长期的效果尚不清楚。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。

ObjectivesTo systematically review the efficacy of Nordic walking on prognosis of cardiovascular diseases. MethodsPubMed, Web of Science, EMbase, The Cochrane Library, CBM, CNKI and VIP databases were electronically searched to collect intervention studies on the efficacy of Nordic walking on prognosis of cardiovascular diseases from inception to June, 2018. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by RevMan 5.3 software. ResultsA total of 9 studies involving 328 patients were included. The results of meta-analysis showed that: compared with control group, there were an obvious decrease in the values of LDL (MD=–11.38, 95%CI –17.51 to –5.25, P=0.000 3), TG (MD=–21.14, 95%CI –32.33 to–9.96, P=0.000 2), SBP (MD=–7.96, 95%CI −11.45 to –4.46, P<0.000 01) and TC, DBP, BMI (P<0.05). However, there were no obvious differences between two groups in HDL. ConclusionsNordic walking can improve the prognosis of patients with cardiovascular diseases, yet the long-term effect is unclear. Due to limited quality and quantity of the included studies, more higher quality studies are required to verify above conclusions.

关键词: 越野行走; 心血管疾病; 预后; 现场干预试验; meta 分析; 系统评价

Key words: Nordic walking; Cardiovascular disease; Prognosis; Field intervention trial; meta-analysis; Systematic review

引用本文: 章志伟, 王梦雪, 杨家鹏, 徐星阳, 金辉. 越野行走对心血管疾病预后影响的 meta 分析. 中国循证医学杂志, 2019, 19(2): 147-155. doi: 10.7507/1672-2531.201711095 复制

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