中国循证医学杂志

中国循证医学杂志

高影响力期刊 2014~2016 年动物实验研究的方法学质量评价

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目的评价国内外高影响力期刊已发表动物实验研究的方法学质量,为提高动物实验的方法学质量和生产高质量的临床前研究提供参考。方法计算机检索中国科学引文数据库(CSCD)和 Web of Science 数据库,搜集所有涉及治疗干预措施的动物实验,检索时限为 2014 年至 2016 年 8 月。由 4 名研究者独立筛选文献、提取资料,并采用 SYRCLE 工具评价纳入研究的方法学质量。结果最终纳入 1 999 个动物实验。超过 90% 的研究被引频次≤5 次,52.53% 的研究被引频次为0。SYRCLE 工具评价结果显示:54.55% 的亚条目的“低风险”的符合率不足 30%,其中 84.62% 的亚条目的“低风险”的符合率低于 10%。结论国内外动物实验研究在方法学设计方面均存在一定问题,国内动物实验研究在实施偏倚、测量偏倚、失访偏倚等方面的问题尤为突出,其“低风险”符合率远低于国外研究。建议采取针对性措施推广与普及 SYRCLE 动物实验偏倚风险评价工具,以有效指导动物实验的开展,提高动物实验的设计和实施质量。

ObjectiveTo evaluate the methodological quality of animal experiments published in high impact journals, in order to provide references for improving the quality of animal experiments.MethodsCSCD and Web of Science databases were electronically searched to collect intervening primordial animal experiments from 2014 to August, 2016. Four reviewers independently screened literatures, extracted data and assessed the methodological quality of included studies by using SYRCLE tool.ResultsA total of 1 999 animal experiments were included. The cited frequency of more than 90% studies were ≤5 times, and of which 52.53% studies were zero. The results of SYRCLE evaluation showed that 54.55% of sub items rated as "low risk" were less than 30%. And 84.62% of them were less than 10%.ConclusionThere are defeet in methodological quality of animal experiments either domestic or abroad. The problems of domestic researches in implementation bias, measurement bias and loss of access bias are particularly obvious. The coincidence rates of "low risk" are much lower than those of abroad studies. Therefore, we suggest that it is necessary to take specific measures to popularize SYRCLE tool to effectively guide the development of animal experiments and improve the design and implementation of animal experiments.

关键词: 动物实验; SYRCLE; 方法学质量; 横断面研究

Key words: Animal experiments; SYRCLE; Methodological quality; Cross-sectional study

引用本文: 赵璐璐, 王欢, 武凯楠, 谢晔, 杜俊宏, 李彦佑, 朱敏, 李婧, 赵梦娜, 魏晨如, 侯皓中, 马彬. 高影响力期刊 2014~2016 年动物实验研究的方法学质量评价. 中国循证医学杂志, 2018, 18(4): 373-378. doi: 10.7507/1672-2531.201709093 复制

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