中国循证医学杂志

中国循证医学杂志

血清瘦素水平与丙型病毒性肝炎相关性的 Meta 分析

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目的系统评价血清瘦素水平与丙型病毒性肝炎(HCV)的相关性。方法计算机检索 PubMed、EMbase、Web of Science、CNKI、CBM、VIP 和 WanFang Data 数据库,搜集有关血清瘦素水平与 HCV 相关的病例-对照研究,检索时间均为建库至 2017 年 7 月。由 2 名研究者独立进行文献筛选、资料提取并评价纳入研究的偏倚风险后,采用 RevMan 5.3 软件进行 Meta 分析。结果最终纳入 11 个研究,包括 1 115 例患者。Meta 分析结果显示,HCV 组的血清瘦素水平高于健康人群组[SMD=0.68,95%CI(0.44,0.91),P<0.000 01]。亚组分析结果显示:检测方法采用 RIA、人群为欧洲人群的丙型病毒性肝炎患者的血清瘦素水平更高,且女性血清素水平高于男性(P<0.000 01)。结论血清瘦素水平与 HCV 相关,且女性血清瘦素水平高于男性。受纳入研究数量和质量的限制,上述结论仍需要开展更多高质量大样本研究来验证。

ObjectivesTo systematically review the association between serum leptin level and hepatitis C virus.MethodPubMed, EMbase, Web of Science, CNKI, CBM, VIP and WanFang Data databases were electronically searched to collect case-control studies on the association between serum leptin level and hepatitis C virus from 2007 to July, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies. Then, meta-analysis was performed by using RevMan 5.3 software.ResultsA total of 11 studies including 1 115 patients were included. The results of meta-analysis showed the serum leptin level was higher in hepatitis C patients than in healthy people (SMD=0.68, 95%CI 0.44 to 0.91, P<0.000 01). The results of subgroup analysis showed that, in hepatitis C patients whose serum leptin levels detected by RIA and European population, serum leptin levels were higher. Women had higher serum leptin levels than men in hepatitis C virus patients (P<0.000 01).ConclusionThe serum leptin level is associated with hepatitis C virus and the serum leptin levels of women are higher than those in men. Due to limited quantity and quality of the included studies, more high quality studies are required to verify above conclusions.

关键词: 血清瘦素; 丙型病毒性肝炎; 系统评价; Meta 分析; 病例-对照研究

Key words: Serum leptin; Hepatitis C; Systematic review; Meta-analysis; Case-control study

引用本文: 张琼元, 徐萱, 罗美, 左国伟, 薛建江, 邱景富. 血清瘦素水平与丙型病毒性肝炎相关性的 Meta 分析. 中国循证医学杂志, 2018, 18(4): 359-364. doi: 10.7507/1672-2531.201709036 复制

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