中国循证医学杂志

中国循证医学杂志

牙周病与结直肠癌发病风险相关性的 Meta 分析

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目的 系统评价牙周病与结直肠癌发病风险的相关性。 方法 计算机检索 PubMed、EMbase、WanFang Data 和 CNKI 数据库,搜集研究牙周病与结直肠癌发病风险相关性的队列研究或病例-对照研究,检索时限均为建库至 2017 年 2 月 28 日。由 2 名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 RevMan 5.3 软件进行 Meta 分析。 结果 最终纳入 5 项前瞻性队列研究。Meta 分析结果显示,牙周病不会增加结直肠癌的患病风险[RR=1.14,95%CI(0.88,1.49),P=0.32]。 结论 当前证据表明,牙周病与结直肠癌的发病风险无相关性。

Objective To systematically review the association between periodontal disease and the risk of colorectal cancer (CRC). Methods PubMed, EMbase, WanFang Data and CNKI databases were electronically searched to collect cohort studies or case-control studies for the association between periodontal disease and the risk of CRC from inception to February 28th, 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, a meta-analysis was performed by using RevMan 5.3 software. Results A total of 5 prospective cohort studies were included. The result of adjusted data based meta-analysis showed that periodontal disease increase was not associated with the risk of CRC (RR=1.14, 95%CI 0.88 to 1.49, P=0.32). Conclusions The current evidence shows that there is no significant association between periodontal disease and the risk of CRC.

关键词: 牙周病; 结直肠癌; 危险因素; 队列研究; Meta 分析; 系统评价

Key words: Periodontal disease; Colorectal neoplasm; Risk Factor; Cohort study; Meta-analysis; Systematic review

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