中国循证医学杂志

中国循证医学杂志

长链非编码 RNA 高表达与胃癌预后不良相关性的 Meta 分析

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目的系统评价长链非编码 RNA(LncRNA)表达水平与胃癌患者临床特征及预后价值的关系。方法计算机检索 PubMed、EMbase、The Cochrane Library、Web of Science、CNKI、VIP、WanFang Data 和 CBM 数据库,搜集有关 LncRNA 高表达与胃癌预后相关性的研究,检索时限均为建库至 2017 年 4 月。由 2 名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用 Stata 12.0 软件进行 Meta 分析。结果共纳入 21 个病例-对照研究。Meta 分析结果显示:LncRNA 高表达胃癌患者 TNM 分期较晚[OR=0.29,95%CI(0.24,0.35),P<0.001]、浸润更深[OR=0.24,95%CI(0.12,0.49),P<0.001]、总生存期(OS)[HR=2.52,95%CI(2.07,3.06),P<0.001]及 无病生存期(DFS)[HR=2.31,95%CI(1.75,3.05),P<0.001]更短。结论胃癌患者 LncRNA 高表达是胃癌预后不良的危险因素。受纳入研究数量和质量的限制,上述结论尚待开展更多高质量研究予以验证。

ObjectivesTo systematically review the association between the expression level of LncRNA and clinicopathological features and prognostic value of gastric cancer.MethodsWe searched PubMed, EMbase, The Cochrane Library, Web of Science, CNKI, VIP, WanFang Data and CBM databases to collect studies on the association between LncRNA overexpression and prognosis for gastric cancer from inception to April 2017. Two reviewers independently screened literature, extracted data and assessed the risk of bias of included studies, then, meta-analysis was performed by using Stata 12.0 software.ResultsA total of 21 case-control studies were included. The results of meta-analysis showed that: LncRNA overexpression patients had poor TNM stage (OR=0.29, 95%CI 0.24 to 0.35, P<0.001), deeper tumor invasion (OR=0.24, 95%CI 0.12 to 0.49,P<0.001), shorter overall survival (OS) (HR=2.52, 95%CI 2.07 to 3.06,P<0.001) and disease-free survival (DFS) (HR=2.31, 95%CI 1.75 to 3.05,P<0.001).ConclusionsLncRNA overexpression is a poor prognosis risk factor for gastric cancer patients. Due to limited quantity and quality of the included studies, more high quality studies are needed to verify above conclusions.

关键词: 长链非编码 RNA; 高表达; 胃癌; 相关性; Meta 分析; 病例-对照研究

Key words: Long non-coding RNA; Overexpression; Gastric cancer; Association; Meta-analysis; Case-control study

引用本文: 龙勃, 展昊, 杜恒锐, 王振江, 郭凌云, 焦作义. 长链非编码 RNA 高表达与胃癌预后不良相关性的 Meta 分析. 中国循证医学杂志, 2018, 18(3): 286-293. doi: 10.7507/1672-2531.201706081 复制

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