中国循证医学杂志

中国循证医学杂志

药物剂量-反应 Meta 分析中的三维模型初探

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剂量-反应 Meta 分析用于探讨不同暴露水平(如药物剂量)与结局之间的剂量效应关系。传统剂量-反应 Meta 分析通常考虑单个自变量暴露对结局的影响。但在药物临床评价中常涉及多个因素(如药物剂量和疗程),这些变量之间通常存在相关性,忽略了这些因素的相关性可能导致估计值出现偏倚。此外,在可能的情况下,同时考虑多个因素与结局之间的关系将更具有临床意义。本文在传统药物剂量-反应 Meta 分析模型的基础上,拟提出同时处理两个暴露因素(药物剂量和疗程)的三维剂量-反应 Meta 分析模型,以期解决上述传统剂量-反应 Meta 分析的问题。

Dose-response meta-analysis serves an important role in investigating the dose-response relationship between independent variables (e.g. dosage) and disease outcomes. Traditional dose-response meta-analysis model is based on one independent variable to consider its own dose-specific effect on the outcome. However, for drug clinical trials, it generally involves two-dimensions of the treatment, such as dosage and course of treatment. These two-dimensions tend to be associated with each other. When neglecting their correlations, the results may be at risk of bias. Moreover, taking account of the "combined effect” of dosage and time on outcome has more clinical value. Therefore, in this article, based on traditional dose-response meta-analysis model, we propose a three-dimension model for dose-response meta-analysis which considers both the effect of dosage and time, to provide a solution for the above-mentioned problems in a traditional model.

关键词: 剂量-反应 Meta 分析; 多变量模型; 协同作用

Key words: Dose-response meta-analysis; Multivariable model; Synergistic effect

引用本文: 徐畅, 李玲, 贾鹏丽, 齐亚娜, 张超, 孙鑫. 药物剂量-反应 Meta 分析中的三维模型初探. 中国循证医学杂志, 2017, 17(12): 1478-1481. doi: 10.7507/1672-2531.201704054 复制

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