An introduction of economic evaluation of N-of-1 trials
1. Traditional Chinese Medicine of Tianjin University, Tianjin, 300193, P.R.China
2. Program Office for Cancer Screening in Urban China, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, P.R.China
3. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, P.R.China
It is potential for N-of-1 trials to evaluate economics of health care, however, it is still in the exploratory stage. With the advantage of accurate estimation of costs and effects, it is beneficial to promote the application of N-of-1 trials for economic evaluation in the era of precision medicine. In this study, we introduce the necessity, feasibility, selection and calculation of indicators and influence factors of N-of-1 trials for economic evaluation. It is useful for researchers to perform related studies.
Scuffham PA, Yelland MJ, Nikles J,et al. Are N-of-1 trials an economically viable option to improve access to selected high cost medications? The Australian Experience. Value Health, 2008, 11(1): 97-109.
Pope JE, Prashker M, Anderson J. The efficacy and cost effectiveness of N of 1 studies with diclofenac compared to standard treatment with nonsteroidal antiinflammatory drugs in osteoarthritis. J Rheumatol, 2004, 31(1): 140-149.