中国循证医学杂志

中国循证医学杂志

试验序贯分析检验 Cochrane 泌尿外科学小组 Meta 分析假阴性结果的研究

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目的 采用试验序贯分析(TSA)检验 Cochrane 泌尿外科学小组累积 Meta 分析假阴性结果。 方法 计算机检索 The Cochrane Library(2016 年第 6 期)“Urology Group”的系统评价,查找具有阴性结果的 Meta 分析。由 2 位研究者独立进行文献筛选和资料提取,然后采用 TSA 0.9β 软件进行 TSA。 结果 共纳入 11 篇文献,包括 12 个 Meta 分析。TSA 结果显示,12 个 Meta 分析中,有 4 个(33%)Meta 分析的结论既未穿过 TSA 界值,也未达到期望信息量,为潜在的假阴性结果。 结论 TSA 可以辅助判断 Meta 分析的结果是否为假阴性结果。

Objective To detect the false-negative results of cumulative meta-analyses of Cochrane Urology Group with the trial sequential analysis (TSA). Methods The Urology Group of Cochrane Library (Issue 6, 2016) were searched to collect meta-analyses with negative results. Two researchers independently screened literature and extracted data of included meta-analyses. Then, TSA was performed using TSA software version 0.9 beta. Results A total of 11 paper involving 12 meta-analyses were included. The results of TSA showed that, four (33%) out of 12 meta-analyses were potentially false-negative results for failing to surpass the trial sequential monitoring boundary and to reach the required information size. Conclusion TSA can help researchers to identify the false-negative results of meta-analyses.

关键词: 试验序贯分析; Meta 分析; 假阴性结果; Cochrane 系统评价

Key words: Trial sequential analysis; Meta-analysis; False-negative result; Cochrane systematic review

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