Comparison study of estimators of between-trial variance in trial sequential analysis for random-effects model
1. Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University; Center for Evidence-Based and Translational Medicine, Wuhan University; Department of Evidence-Based Medicine and Clinical Epidemiology, The Second Clinical Medical College of Wuhan University, Wuhan, 430071, P.R.China
2. Department of Urology, Peking University First Hospital, Beijing, 100034, P.R.China
3. Department of Urology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710061, P.R.China
4. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, 430071, P.R.China
The assumption of fixed-effects model is based on that the true effect of the each trial is same. However, the assumption of random-effects model is based on that the true effect of included trials is normal distributed. The total variance is equal to the sum of within-trial variance and between-trial variance under the random-effects model. There are many estimators of the between-trial variance. The aim of this paper is to give a brief introduction of the estimators of between-trial variance in trial sequential analysis for random-effects model.
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